Phage therapy is a promising approach to combat Antimicrobial Resistance (AMR). AMR occurs when bacteria develop resistance to antibiotics, rendering these drugs ineffective in treating bacterial infections. Phages, also known as bacteriophages, are viruses that infect and kill specific bacteria. Phage therapy involves using these viruses to target and destroy antibiotic-resistant bacteria.
Here's how phage therapy works in the context of AMR:
Identifying the target bacteria: The first step in phage therapy is to identify the specific antibiotic-resistant bacteria causing the infection. This is crucial because phages are highly specific to certain bacterial strains and cannot infect other bacteria.
Isolating and characterizing phages: Once the target bacteria are identified, phages that are effective against them need to be isolated and characterized. Phages can be found in various environments, such as sewage, water sources, and soil. Researchers isolate and study phages to ensure their safety and effectiveness before using them in therapy.
Creating phage preparations: Phages are multiplied in the laboratory through a process called amplification, resulting in phage preparations with high concentrations of active viruses. These preparations are then used for treatment.
Administering phage therapy: Phage therapy can be administered in various ways, depending on the type of infection. It may be given orally, topically, or through intravenous injections. The goal is to deliver the phages directly to the site of the infection.
Monitoring and adjusting treatment: During phage therapy, patients are closely monitored to assess the effectiveness of the treatment and any potential side effects. If needed, the phage preparation may be adjusted or combined with other therapies, including antibiotics.
Advantages of Phage Therapy for antibiotic-resistant (AMR):
Challenges and Limitations:
Case Study:
Randomized Trial: Evaluating the Efficacy of Two Coliphage Preparations for Treating Acute Bacterial Diarrhea in Children from Bangladesh Using Oral Phage Therapy.
To know more about this Case Study click on >> National Library of Medicine
